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银屑病光疗靠谱么,能与他卡西醇联合使用吗?合理选择是关键-健康用药-西安康桐网络科技有限公司

银屑病光疗靠谱么,能与他卡西醇联合使用吗?合理选择是关键

2015-11-18 19:32:37

银屑病是一种环境与遗传等共同作用诱发的慢性、复发性、免疫系统疾病,俗称“牛皮癣”,典型的临床表现为干燥的鳞屑性红斑或斑块,界限清楚、大小不等。皮损的好发部位主要为头部、甲、四肢伸侧、脐部和骶部,膝肘部常常对称发生。全球有超过1.25亿银屑病患者,我国银屑病患病率为0.47%,据此估计,我国银屑病患者约650万[1],给患者的生活带来较大的痛苦。


银屑病病情反复,目前还没有特效药能完全根治,但通过配合医疗手段,也是可以较好地控制皮损、减少复发频率,改善患者生活质量,达到“临床治愈”的目的。常见的治疗方法有外用药物治疗、口服全身系统治疗、生物制剂治疗、物理治疗。其中光疗就是属于物理治疗,也是临床中重度银屑病患者常用的一种治疗方法。


  那么银屑病光疗靠谱吗?

  光疗法通常指的是紫外线光疗法,通过抑制表皮增生变厚减轻皮肤炎症,从而减少皮肤的损伤。银屑病光疗法主要有4种,包括有准分子激光治疗、中波紫外线B(UVB)、窄波UVB(NB-UVB)、光化学疗法(PUVA)。


  其中UVB相较下会比较方便和便宜,患者可以自己在家里使用光疗机进行UVB光疗。操作方式是以特定时间将皮肤暴露在紫外线下,可以设置为中波紫外线(UVB,波长为280-320 nm)发挥作用。UVB光疗具有不同的特性,如抗炎、免疫抑制和细胞毒性。如果银屑病皮损发生在较薄部位,那么光疗的效果相对会较明显。


  光疗被纳入中国银屑病诊疗指南(2018版)里面,统计约70%-80%的银屑病患者在规律光疗2-3个月后,皮损可以达到七八成的缓解,从而缩短银屑病的治疗疗程。光疗法是治疗中重度银屑病的重要手段,可以改善不能用别的方法控制的可致残的银屑病,也可以用于其他疗法的联合治疗。


  紫外线光疗联合局部外用药可增强治疗银屑病的效果


  紫外线光疗由于治疗过程仅发生在皮肤表层,对于身体损伤较小,是一种安全性较高的治疗方法。但是这种治疗方法会有一定的局限性及也会带来一下副作用,所以,临床上常常会关联其它药物进行治疗,以提升治疗效果和减少不良反应,常用关联的药物包括以下两种。


  1、保湿剂:


  目前安全性较高的辅助治疗药物,在银屑病治疗的所有过程都可以使用。一般建议一天多次涂抹,以达到覆盖皮肤表层。从而减少水分流失,避免银屑病症状加重。


  2、维生素D3衍生物:


  大多数的银屑病患者,使用外用药物是首选的治疗方案。根据皮损分布部位不同,药物有不同的选择。头皮部银屑病可选用煤焦油剂如复方去煤液;面部皮损宜采用非激素制剂如他卡西醇等,刺激性和副作用较小;躯干、四肢斑块状皮损可用地蒽酚、维A酸、中强效激素以及卡泊三醇等治疗,但不主张长期大量使用。


在银屑病指南中,维生素D3衍生物是可以治疗轻中度银屑病的一线局部药物。其中他卡西醇刺激性较小,患者耐受性好,能够抑制表皮细胞增殖、促进角质分化、调节免疫等,使异常增殖的皮肤患处恢复正常。据相关研究显示,他卡西醇联合紫外线光疗仪治疗寻常型银屑病时,在治疗的第二周开始,皮损就可以得到改善。如果联合UVB光疗治疗,则光疗一周3次,他卡西醇一天2次。推荐每天早晚各用一次,由于刺激性较小,在脸部以及大腿内侧等薄嫩的皮肤都可以使用。


  他卡西醇与NB-UVB联合治疗寻常型斑块状银屑病时,提示其改善银屑病效果较好。其主要因素可能是在治疗上具有协同或叠加作用,导致联合治疗与单用治疗之间形成差异。作为大面积复发的常用治疗方法,光疗与他卡西醇联合能够缓解银屑病皮损,合理搭配外用药物联合应用还能提高治疗效果及减少复发。


  除了正确用药外,还要做好相关护理工作!

目前对于银屑病的治疗仍然处于控制阶段,虽然无法保证治疗后永不复发,但只要经过科学的治疗和预后,维持正常质量的生活还是比较容易的,在日常生活中,要穿着干净柔软的棉质衣服,避免对身体的伤害;平时可以用清水洗澡,使用中性的肥皂或沐浴露;沐浴后可以使用润肤剂来修复受损的肌肤屏障,从而降低病情的复发。


参考文献:

[1] 中华医学会皮肤性病学分会银屑病专业委员会.中国银屑病诊疗指南(2018简版)

[2] 银屑病光疗的应用及疗效[J]. 国际医药卫生导报,2022,28(5):598-602